Imaging End Points in COPD Clinical Trials
نویسندگان
چکیده
منابع مشابه
Composite end points in clinical trials.
Composite endpoints are often used in clinical trials, especially in the cardiovascular area. Decreases in sample size requirements, ability to assess the net effect of an intervention and to avoid bias in presence of competing risk are the most cited advantages for their use. However, there is a risk of misinterpretation when heterogeneity among components with respect to either importance, nu...
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Background—Although most clinical trials of coronary stents have measured nominally identical safety and effectiveness end points, differences in definitions and timing of assessment have created confusion in interpretation. Methods and Results—The Academic Research Consortium is an informal collaboration between academic research organizations in the United States and Europe. Two meetings, in ...
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Phase 3 clinical trials, which evaluate the effect that new interventions have on the clinical outcomes of particular relevance to the patient (such as death, loss of vision, or other major symptomatic event), often require many participants to be followed for a long time.There has recently been great interest in using surrogate end points, such as tumor shrinkage or changes in cholesterol leve...
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Acute heart failure syndromes (AHFS) remain a major cause of morbidity and mortality, in part because the development of new therapies for these disorders has been marked by frequent failure and little success. The heterogeneity of current approaches to AHFS drug development, particularly with regard to end points, remains a major potential barrier to progress in the field. End points involving...
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C hronic kidney disease (CKD) worsens over time by transitions through a sequence of stages, regardless of the specific cause of kidney damage or rate of progression (Figure 1). Recent guidelines and public health campaigns have focused on early detection and treatment of CKD on the basis of the rationale that treatments that are initiated early in the disease course will have a greater effect ...
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ژورنال
عنوان ژورنال: Chest
سال: 2018
ISSN: 0012-3692
DOI: 10.1016/j.chest.2018.01.050